Diminished interest constitutes a core behavioral deficit across multiple neuropsychiatric conditions, yet its neural mechanism remains poorly understood. Here, we identify projection-biased and transcriptionally distinct subsets of glutamatergic neurons in the ventromedial prefrontal cortex (vmPFC) that preferentially innervate the anterior piriform cortex (APC) and posterior piriform cortex (PPC). By establishing a behavioral paradigm that selectively captures interest-related behaviors, we reveal that the vmPFCglu-PPC, but not the vmPFCglu-APC, circuit governs interest-related engagement without affecting olfactory function. This regulation is encoded by AMPAR-dependent burst firing in PPC neurons. Chronic stress selectively weakens this cortico-cortical pathway, reducing glutamatergic transmission and impairing burst firing in PPC neurons, thereby leading to deficits in interest-related behavior in mice. Targeted reactivation of the vmPFCglu-PPC circuit rescues these behavioral impairments. Collectively, our findings uncover a previously unrecognized cortical pathway dedicated to interest encoding and establish a circuit-level framework for explaining the selective vulnerability of interest under chronic stress.
White matter hyperintensities (WMHs), a hallmark of cerebral small vessel disease, frequently coexist with Alzheimer's disease (AD) and facilitate cognitive deterioration. Juxtaventricular WMH (JVWMH) is hypothesized to reflect pathological processes at the cerebrospinal fluid (CSF)-parenchyma interface and hold particular clinical significance. Therefore, this study specifically investigated associations between JVWMH burden and cognitive performance, CSF volume (CSFV), and amyloid-β (Aβ) pathology. Automated WMH segmentation was applied in two cohorts: 295 from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study and 82 from a memory clinic. All participants underwent 3-T magnetic resonance imaging, amyloid-positron emission tomography, and cognitive assessment. Analyses evaluated JVWMH associations with Aβ, its discriminative value for cognitive impairment (CI) versus cognitively normal (CN), prediction of longitudinal decline, and mediation of CSFV-cognition relationships. JVWMH volume significantly discriminated CI from CN participants in both cohorts and predicted cognitive decline in longitudinal AIBL data. JVWMH volume showed strong correlations with CSFV in both cohorts. Notably, JVWMH partially mediated the associations between CSFV and cognition in the AIBL cohort. Non-juxtaventricular WMHs and Fazekas scores demonstrated no significant diagnostic or predictive power. JVWMH volume provides diagnostic and prognostic information beyond conventional WMH metrics in AD. Its correlation with CSFV implicates CSF-parenchyma interface processes, though causality remains unproven. These findings highlight the importance of incorporating spatially stratified WMH metrics in AD research to better capture disease-relevant white matter pathology. Question: JVWMH volume provides diagnostic and prognostic value beyond conventional WMH metrics in AD. Findings: JVWMH volume discriminated CI from normal cognition, predicted longitudinal decline, correlated with CSF volume, and partially mediated CSF volume–cognition associations. Relevance statement: JVWMH volume provides diagnostic and prognostic information beyond conventional WMH metrics in AD, highlighting the value of spatially stratified WMH analysis in AD research to better capture disease-relevant white matter pathology. Question: JVWMH volume provides diagnostic and prognostic value beyond conventional WMH metrics in AD. Findings: JVWMH volume discriminated CI from normal cognition, predicted longitudinal decline, correlated with CSF volume, and partially mediated CSF volume–cognition associations. Relevance statement: JVWMH volume provides diagnostic and prognostic information beyond conventional WMH metrics in AD, highlighting the value of spatially stratified WMH analysis in AD research to better capture disease-relevant white matter pathology.
Yi-Wen Bao, Ya-Qing Ji, Li-Na Wang et al.· European Radiology Experimen...· 0 citations
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