Blood transcriptomic signatures link β-amyloid deposition to molecular pathways across SCD, MCI, and dementia
Introduction Brain β-amyloid (Aβ) accumulation is a hallmark of Alzheimer’s disease, but noninvasive detection remains challenging. Blood transcriptomics may provide accessible biomarkers associated with Aβ pathology. Methods We integrated peripheral blood transcriptomic profiling and MRI-derived structural metrics fro...