Dengue virus (DENV) is a mosquito-borne orthoflavivirus that infects millions of people annually across tropical and subtropical regions, posing a severe and growing threat to global public health. Currently there are no antiviral drugs available for DENV infection. The methyltransferase domain of non-structural protei...
Chen-Chen Li, Jian-Fang Zhang, Yue-Gao Hu et al.· International Journal of Bio...· 0 citations
Current influenza vaccination strategies are constrained by the trade-off between the safety of inactivated platforms and the immunogenic potency of live attenuated vaccines. Here, we provide a comprehensive demonstration that subcutaneous (SC) immunization with a non-attenuated, replication-competent live influenza A...
The main protease (Mpro) is a prime target for anti-SARS-CoV-2 drugs. Herein, we describe the structure-based covalent modifications that generate new nonpeptidic covalent Mpro inhibitors. The compounds exhibit strong inhibition against Mpro at submicromolar levels. The deuterated lead compound exhibits submicromolar...
Honglei Bao, Ling-Chen Sun, Shilin Gong et al.· ACS Bio & Med Chem Au· 0 citations
Substantial lipid metabolic disturbances following acute DQ poisoning are demonstrated and candidate lipid markers that warrant further evaluation for diagnosis and prognosis are identified.
Xin-Xin Huang, Xu-Nan Kan, Lei Xiao et al.· Toxicology and Applied Pharm...· 0 citations
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