Discordant CYP2C19 genotype-phenotype relationship in voriconazole metabolism: impact of inflammation on drug exposure in a Chinese patient.
A case of a 49-year-old Chinese woman with essential thrombocythaemia who was treated with voriconazole for possible invasive pulmonary aspergillosis, who required unusually high doses to achieve therapeutic voriconazole concentrations without apparent adverse effects under therapeutic drug monitoring (TDM).