Open access
Aug 2026
Discovery of Highly Selective Noncovalent Macrocyclic Peptide Inhibitors Suppressing Both TMPRSS2 Protease Activity and Viral Receptor Function
MCPs are highlighted as promising, highly selective TMPRSS2-directed antiviral lead compounds that exhibited dual functionality by inhibiting both the enzymatic and receptor functions of TMPRSS2, as demonstrated by their blockade of the HKU1 coronavirus spike protein binding.
Benjamin J. Tombling, Gabriel Lemieux, Alexandre Joushomme et al.
· Journal of Medicinal Chemist... · 0 citations