Aug 2026
USP16 functions as a novel deubiquitinase of YAP and a therapeutic target of isorhamnetin in gastric cancer.
Yehua Li, S. Ren, Qin Zhang et al.
· Phytomedicine · 0 citations
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Open access
Sep 2026
DFRL-Mol: a dual-stage framework of reinforcement learning for multi-scenario molecule optimization
Abstract As a critical step in drug discovery, molecule optimization aims to improve specific properties of lead compounds. Inspired by isosteres (i.e. molecular substructures with similar reactive electron shells), existing AI-based methods have been proposed for molecule optimization. However, they often rely on avai...
Zhen-Yi Wu, Peng-Cheng Zhao, Jia-Ning Li et al.
· Briefings in Bioinformatics · 0 citations
Review
Jul 2026
Three-Dimensional Bioprinting-Enabled Organoids for Engineering the Tumor Microenvironment.
The tumor microenvironment (TME) is a complex and dynamic system composed of immune cells, stromal cells, and extracellular matrix (ECM), whose composition and spatial architecture critically influence tumor initiation, progression, invasion, metastasis, and response to immunotherapy. However, traditional research mode...
Yehua Li, Jiale Shi, Qin Zhang et al.
· Tissue engineering. Part B,... · 0 citations