C21 ameliorates microglial ferroptosis and neuronal apoptosis after ischemic brain injury by activating the METTL3/USP18/FASN axis.
BACKGROUND Microglial ferroptosis is a key risk factor promoting neuroinflammation after ischemic brain injury (IBI). Although Compound 21 (C21) has neuroprotective and anti-inflammatory properties, its role in modulating microglial ferroptosis in IBI remains unexplored. METHODS IBI was induced in C57BL/6 mice via tr...