Repair of large segmental bone defects requires implanted scaffolds not only to provide sufficient structural stability but also to accommodate the pronounced spatial heterogeneity, anisotropy, and load-dependent nonlinear behaviour of native bone while establishing a local mechanical microenvironment conducive to tiss...
Xing-Zhen Li, Jin-Bo Zhang, Hao Chen et al.· International Journal of Bio...· 0 citations
Ti6Al4V implants are used to repair critical-sized bone defects, but their bioinert surfaces often cause insufficient early osteogenic stimulation, potentially leading to compromised long-term fixation. The osteogenic microenvironment is vital for osseointegration between the host bone and the implant and influences lo...
Xiang-Ping Yue, Wen-Bo Yang, Hao Chen et al.· Bio-Design and Manufacturing· 0 citations
The tendon–bone interface anchors compliant tendon to rigid bone through continuous gradients in collagen orientation, proteoglycan content, mineralization, and local modulus. After adult injury, this spatiotemporal organization is difficult to restore, and repair typically produces a fibrous connection rather than a f...
Zhao-Wei Zhang, Hao Chen, Jin-Bo Zhang et al.· International Journal of Bio...· 0 citations
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