Sequential Unlocking of an RNS/ROS Storm via a Four-Layer Logic‑Gated Ruthenium Nanocomposite for Hypoxia-Tolerant Photodynamic Cancer Immunotherapy.
Tumor hypoxia, an immunosuppressive microenvironment, and the lack of spatiotemporally precise therapeutic activation collectively limit current cancer treatments. Here, we report a smart nanocomposite (G&Ru@CuS) that produces a localized reactive nitrogen species (RNS)/reactive oxygen species (ROS) storm controlled by...