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Author

Qing-Hua Shen

3 papers indexed here

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Sep 2026

Sequential Unlocking of an RNS/ROS Storm via a Four-Layer Logic‑Gated Ruthenium Nanocomposite for Hypoxia-Tolerant Photodynamic Cancer Immunotherapy.

Tumor hypoxia, an immunosuppressive microenvironment, and the lack of spatiotemporally precise therapeutic activation collectively limit current cancer treatments. Here, we report a smart nanocomposite (G&Ru@CuS) that produces a localized reactive nitrogen species (RNS)/reactive oxygen species (ROS) storm controlled by...

Peng Wang, Long-Bo Yu, Qing-Hua Shen et al. · 0 citations
Jul 2026

Self-Sustaining Catalytic-Immunological Cycle Powered by a Tumor Microenvironment-Engineered Iridium-MnO2 Nanozyme for Photodynamic Immunotherapy.

Overall, this work introduces an innovative nanoplatform that establishes a self-reinforcing cycle of hypoxia alleviation and immune activation, offering a potent combinatorial strategy to surmount PDT resistance and amplify antitumor immunity.

Peng Wang, Ying-Ying Han, Qing-Hua Shen et al. · 0 citations
Open access Jul 2026

A molecularly engineered rhenium platform triggers a self-enhancing RNS storm to disrupt tumor hypoxia and resultant immunosuppression

This RNS-amplifying nanoplatform represents a strategy that moves beyond conventional PDT by synergistically integrating gas therapy and checkpoint downregulation to remodel the tumor microenvironment and amplify antitumor immunity.

Long-Bo Yu, Qing-Hua Shen, Shuo-Ting Huang et al. · 0 citations

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