Solvent-Controlled Diastereoconvergent Synthesis of Spirochromeno[4,3-b][1,3]pyrrole-Cyclopropanes through 2,3-Rearrangement-Driven Cyclopropanation of O-Propargyl Oximes with Sulfur Ylides.
Herein, a variety of spirochromeno[4,3-b][1,3]pyrrole-cyclopropanes bearing four contiguous stereocenters were prepared in moderate to good yields with high diastereoselectivity through copper(I)-catalyzed 2,3-rearrangement-driven cyclopropanation of O-propargylic oximes with sulfur ylides. Mechanistic studies revealed...