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Author

Qing Peng

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Aug 2026

TAGLN2 promotes mesenchymal circulating tumor cell-associated metastasis through the CSNK1E-YAP Axis with concomitant EMT induction and metabolic remodeling in hepatocellular carcinoma.

Postoperative recurrence and hematogenous metastasis remain major barriers to long-term survival in hepatocellular carcinoma (HCC). Mesenchymal circulating tumor cells (mCTCs) are closely associated with HCC recurrence and metastasis, yet the key regulatory mechanisms and accompanying circulating metabolic alterations...

Lei Luo, Zhuohao Chen, Junxi Chen et al. · 0 citations
Open access Jul 2026

Single-Cell Dissection of the Immune Microenvironment in Intrahepatic Metastasis of Multifocal Hepatocellular Carcinoma

Findings identify GPNMB-positive macrophages as key metabolic and immune regulatory hubs, suggesting that targeting the GPNMB–prostaglandin E2 axis provides a promising precision therapeutic strategy for intrahepatic metastasis in multifocal hepatocellular carcinoma.

Yuyan Xu, Cheng Zhang, Zhuo-Cheng Ji et al. · 0 citations

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