Author

Qing-Ping Shi

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Review Open access Aug 2026

Lactate as a Master Regulator of Immune Suppression: From Metabolic Waste to Epigenetic Checkpoint in Colorectal Cancer

Targeting lactate metabolism through LDHA or MCT4 inhibition, modulation of histone lactylation, or disruption of lactate-lipid crosstalk, when combined with classical immune checkpoint blockade and guided by spatial biomarkers, offers a promising strategy to overcome immunotherapy resistance in this challenging subtyp...

Bei-Yan Chen, Shuang Gao, Xin Chen et al. · International Journal of Mol... · 0 citations

Open access Sep 2026

Integrated Metabolic and Immune Molecular Subtyping and a Molecular Classification Score for Revealing Disease Heterogeneity in Pulmonary Arterial Hypertension

MIRS provides a molecular stratification basis for subtype discrimination and a hypothesis-generating framework for future therapeutic investigations and failed to discriminate PAH from controls in PBMCs, indicating that this tissue-derived signature is not readily detectable in peripheral blood.

Xin Chen, Yue-Tong Zhu, Qing-Ping Shi et al. · Metabolites · 0 citations

Open access Aug 2026

Exploring the Molecular Mechanism of Cinnamaldehyde Intervening in Ochratoxin A-Induced Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease Comorbidity: An Integrated Approach Based on Network Pharmacology, Network Toxicology and Molecular Docking

An integrated network toxicology and network pharmacology approach was employed to jointly decipher the potential mechanisms by which CA intervenes in OTA-induced comorbid T2DM-NAFLD comorbidity.

Ming-Li Shen, Qing-Ping Shi, Shuang Gao et al. · Pharmaceuticals · 0 citations