Qing Shao

Benchmark Averages Hide the Failures That Matter: Quantizing ESM-2 for Protein Variant-Effect Prediction

We benchmark six numerical precision configurations for ESM-2 protein language models across throughput, memory footprint and predictive accuracy, on two workloads with sharply different characteristics: bulk embedding extraction and deep mutational scanning (DMS) variant-effect scoring. Accuracy is evaluated on the co...