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Engineering a Streptomyces albidoflavus cell factory for heterologous biosynthesis of tsukubarubicin

Tsukubarubicin is a nogalamycin-type anthracycline antibiotic with potent cytotoxic activity against human breast cancer cells, making it a promising antitumor candidate. However, its native producer produces only trace amounts of tsukubarubicin and is slow-growing and genetically intractable, limiting further ph...