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Qing-Xiang Lin

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Sep 2026

Abstract PR012: Encoding adaptive mechanisms of resistance to KRAS inhibition in pancreatic cancer

Clinical outcomes for pancreatic ductal adenocarcinoma (PDAC) remain poor. Although ∼90% of PDAC tumors harbor oncogenic KRAS mutations and KRAS inhibitors (KRASi) have shown clinical promise, adaptive resistance limits response depth and durability. While EGFR-mediated RAS-MAPK pathway reactivation has been impl...

Qing-Xiang Lin, Bo-Kai Song, C. Sander et al. · 0 citations

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