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Review Oct 2026

Genome-scale metabolic models enable predictive strain and process design for sustainable biomanufacturing.

Genome-scale metabolic models (GEMs) have emerged as powerful tools for optimizing microbial fermentation. This review traces the application of GEMs from model reconstruction through to industrial implementation. Automated reconstruction tools including CarveMe, ModelSEED, and RAVEN are discussed alongside quality-con...

Shuai-Shuai Xu, Ji Ding, Shu-Yi Chen et al. · 0 citations
Aug 2026

Rational Engineering of Chitosanase for Producing Higher-Degree-of-Polymerization Chitooligosaccharides and Evaluating Their Antibacterial Properties.

A rational design strategy was developed to increase the DP of COS by introducing three negatively charged mutations into chitosanase Csn168 (a chitosanase from Bacillus subtilis 168) and the resulting high-DP COS exhibited potent antibacterial activity against Staphylococcus aureus.

Zhangyi Chen, Jiawei Luo, Chenglin Wu et al. · 1 citation

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