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Open access Oct 2026

Favezelimab/Pembrolizumab Coformulation Versus Standard-of-Care in PD-L1–Positive Metastatic Colorectal Cancer: The Phase III, Randomized KEYFORM-007 Study

The phase III KEYFORM-007 study (ClinicalTrials.gov identifier: NCT05064059 ) evaluated the efficacy and safety of coformulated favezelimab/pembrolizumab versus standard-of-care (SOC) in PD-L1–positive microsatellite stable/mismatch repair proficient (MSS/pMMR) metastatic colorectal cancer (mCRC). We present re...

N. Segal, Maria Passhak, F. Kose et al. · 0 citations
Open access Oct 2026

PRV-Induced mROS–HIF-1α Pathway-Mediated Glycolysis to Promote Replication

Viruses have evolved numerous mechanisms to target key metabolic pathways in the host, thereby reshaping host metabolism to establish a metabolic environment conducive to their replication. We previously observed that pseudorabies virus (PRV) infection upregulates cellular glycolysis, but the mechanism is not clear. He...

Qing Xu, Yu Wang, Yu-Lin He et al. · 0 citations

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