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Qing-Xuan He

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Open access Aug 2026

Extracellular vesicles from human adipose-derived mesenchymal stem cells reprogram macrophage lipid metabolism via the ABCF1/CPT1A/IL-10 axis to mitigate sepsis-induced acute lung injury

Sepsis-induced acute lung injury (ALI) is a life-threatening syndrome characterized by overwhelming inflammation, immune dysregulation, and tissue damage. Metabolic reprogramming of macrophages has emerged as a central regulator of inflammatory responses. Extracellular vesicles (EVs) derived from mesenchymal stem cel...

Ling-Yu Zhang, Dainian Guo, Qing-Xuan He et al. · Cell Death Discovery · 0 citations

Aug 2026

Erchen Decoction Alleviates MAFLD by Regulating MFN2-mediated Endoplasmic Reticulum Stress.

EC exerts significant protective effects against MAFLD by upregulating the MFN2/ERMIT2 axis and suppressing the PERK, eIF2α, and ATF4 ERS pathway, suggesting a restorative effect on calcium handling, maintains ER homeostasis, and reduces hepatocyte injury, highlighting EC as a promising therapeutic candidate for MAFLD.

Qing-Xuan He, Meng-Zhen Wang, Xu Wang et al. · Endocrine, Metabolic & Immun... · 0 citations

Aug 2026

Identification of Lactate-related Biomarkers in Non-alcoholic Fatty Liver Disease.

These findings bridge the gap between metabolic lipotoxicity and epigenetic regulation, suggesting that lactylation acts as a critical driver in NAFLD pathogenesis.

Qing-Xuan He, Xu Wang, Peng-Fei Wang et al. · Endocrine, Metabolic & Immun... · 0 citations