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Author

Qingxue Hu

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Open access Oct 2026

Design, synthesis, and evaluation of antifungal and antibacterial activities of novel quinazolinone-formononetin derivatives.

BACKGROUND Plant pathogenic fungi and bacteria cause substantial losses in agricultural production worldwide, and escalating resistance to conventional agrochemicals necessitates the development of novel, environmentally benign pesticides. Formononetin, a naturally occurring isoflavone, exhibits promising bioactivities...

Xiao-Yan Pan, Jun-Rong Song, Qing-Xue Hu et al. · 0 citations
Oct 2026

Acylpiperidine Formononetin Derivatives as Antimicrobial Lead Compounds: Activity and Preliminary Mode-of-Action Studies

Global agricultural production relies heavily on chemical pesticides, leading to resistance, residues, and pollution, threatening sustainable agriculture. There is an urgent need to develop novel antimicrobial agents from low-toxicity, easily degradable natural products. Using formononetin as a lead compound, acylpip...

Fang Tian, Miao-He Zhang, Qing-Xue Hu et al. · 0 citations
Aug 2026

Discovery of Novel Carbohydrazide-Containing Formononetin Derivatives as Potential Broad-Spectrum Antifungal Agents.

In vivo antifungal assays conducted on rice leaves and kiwifruit demonstrated that X4 displayed satisfactory protective and curative effects, and molecular docking experiments combined with SDH activity assays indicated that X4 engages in favorable interactions with SDH.

Xiao-Yan Pan, Dan Shen, Han Yang et al. · 0 citations
Jul 2026

Design, synthesis and bioactivity of benzoxazinone-containing formononetin derivatives.

BACKGROUND Phytopathogens have long compromised the yield and quality of crops worldwide, and the overuse of conventional synthetic pesticides has engendered a series of ecological and environmental issues. Consequently, the development of low-toxicity, high-efficacy and environmentally benign pesticides has become an...

Han Yang, Xiaoyan Pan, Dan Shen et al. · 0 citations
Aug 2026

Synthesis and antifungal activity evaluation of flavonol derivatives containing an imidazolidinone moiety.

Findings indicate that H7 could serve as a lead compound for the development of novel fungicides against kiwifruit soft rot and preliminary mechanistic investigations suggested that the antifungal activity of H7 is associated with disruption of cell membrane integrity and inhibition of succinate dehydrogenase activity.

Qing-Xue Hu, Xiao-Ting Geng, Xiao-Yan Pan et al. · 0 citations
Jul 2026

Design, Synthesis, and Antifungal Evaluation of Novel Formononetin-Benzothiazole Hybrids with Preliminary Mechanistic Insights.

Although the precise molecular target remains unknown, H2 shows promise as a lead candidate, and the benzothiazole moiety appears critical for enhancing activity, and the preliminary basis for developing eco-friendly fungicides is provided.

Dan Shen, Xiaoyan Pan, Han Yang et al. · 0 citations
Aug 2026

Novel Flavonol Derivatives Bearing a 1,2,3,4-Tetrahydroquinoline Moiety: Design, Synthesis, and Anti-Phytophthora capsici Activity.

Mechanistic studies revealed that Q8 disrupted cell membrane integrity and inhibited succinate dehydrogenase (SDH) activity, with computational simulations suggesting a higher binding affinity for SDH than fluopyram.

Qing-Xue Hu, Xiao-Ting Geng, Fang Tian et al. · 0 citations

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