Aug 2026
Discovery and Characterization of RP04340: A Highly Potent and Orally Active Pan-KRAS PROTAC Degrader.
RP04340 potently degrades multiple KRAS mutants, without affecting HRAS, NRAS, or known CRBN neosubstrates, and exhibits robust antiproliferative activity in various cancer cell lines, representing a compelling candidate for KRAS-driven cancers.
Xiang Ji, Yue-Ning Du, Qi-Guo Zhang et al.
· Journal of Medicinal Chemist... · 0 citations