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Q. Luo

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Aug 2026

A novel TK/gE-deleted pseudorabies virus vaccine expressing CCL3L1 enhances humoral immunity by stimulating the dendritic cell-T follicular helper-germinal center axis.

Pseudorabies virus (PRV) remains a major threat to the swine industry, particularly due to the emergence of highly virulent PRV variants that have caused severe outbreaks in Asia in recent years. These emerging strains exhibit enhanced pathogenicity and immune evasion, resulting in insufficient protection by traditiona...

Lun Yao, Si-Wen Hao, Chengjun Zhang et al. · 0 citations
Open access Jul 2026

Inhibition of Pseudomonas aeruginosa-secreted protease IV reduces lung inflammation

PpL is established as a key virulence factor that triggers AP-1-mediated inflammatory signaling, structural and functional insights into PrpL inhibition are provided, and AprA is identified as a novel upstream PrpL activator, highlighting PrpL as a promising anti-virulence therapeutic target.

S. Daboor, Lauren D. Burton, Trilok Neupane et al. · 0 citations

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