Open access
Jul 2026
Host OTUB2 and viral PLpro stabilize NSP8 to promote SARS-CoV-2 replication
The ubiquitin-proteasome system (UPS) plays a central role in antiviral defense but is also frequently hijacked by viruses to facilitate their replication. Here, we demonstrate that the host deubiquitinase OTUB2 stabilizes the viral replication factor NSP8 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
Wenying Gao, Hongfei Wang, Jingguo Xin et al.
· Virologica Sinica · 0 citations