Open access
Aug 2026
Recipient Endothelial IRF1 mediates IFNγ-driven tissue tolerance in mouse models of acute Graft-versus-Host Disease.
A role is identified for the lymphatic endothelial IFNγ-IRF1 axis in regulating early vascular remodeling, donor T cell mediated tolerance, underscoring a potential "goldilocks" level of pathway activation required to improve post-transplant outcomes.
Lotus Neidemire-Colley, Rathan Kumar, Elizabeth A. R. Garfinkle et al.
· Blood · 0 citations