Author

Qiu-Yue Zhang

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Open access Sep 2026

Design, Synthesis and Antitumor Activity Evaluation of Novel Dual G9a/EZH2 Inhibitors

Targeting the crosstalk between histone methyltransferases G9a and EZH2 represents a promising strategy for cancer therapy. To improve upon our previously reported dual inhibitor SU08, we rationally designed and synthesized five series (SU, UA, UB, N, and L) of novel G9a/EZH2 dual inhibitors, incorporating diverse pyri...

Ya-Jie Shi, Qiu-Yue Zhang, Ma-Zhong Zhang et al. · Molecules · 0 citations

Review Open access Aug 2026

Modulating phosphorylation by proximity-inducing strategy: an update.

These studies highlight the expanding scope of proximity-induced phosphorylation control, while emphasizing that broader application will depend on improved molecular design and a clearer understanding of proximity-driven mechanisms.

Yuxin Xia, Daichao Zhai, Qi-Dong You et al. · RSC Medicinal Chemistry · 0 citations