Src tyrosine kinase mediates Zn2+-induced myocardial protection against endoplasmic reticulum stress and ischemia/reperfusion injury.
OBJECTIVE To investigate the role of Src tyrosine kinase in Zn2+-induced cardioprotection and the mechanisms involving endoplasmic reticulum stress (ERS), mitochondrial dysfunction, and mitochondrial calcium regulation. METHODS H9c2 cells were used to establish in vitro models of ischemia/reperfusion (I/R) injury and...