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Aug 2026

Lactate facilitates Largemouth bass virus replication by promoting cholesterol biosynthesis.

Cellular metabolism has been hijacked by viruses for efficient replication due to their regulatory roles on both innate and adaptive immunity. Largemouth bass virus (LMBV), a member of Ranavirus, causes high mortality and severe economic losses in several fish species, seriously threatening the sustainable development...

Xixi Guo, Ting Yu, Yin Zhao et al. · 0 citations
Aug 2026

Largemouth bass virus infection subverts immune-redox homeostasis in zebrafish and is associated with coordinated suppression of NF-κB and Nrf2 signaling.

From lower vertebrates to higher mammals, oxidative stress and inflammatory responses form a tightly regulated homeostatic network, yet the virus-specific mechanisms that coordinate these processes remain unclear. Here, we investigated this question using Largemouth bass virus (LMBV) in both zebrafish in vivo infection...

Lingfeng Guan, Xinyue Zhang, Ting Yu et al. · 0 citations

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