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Author

Quanhao Dou

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Sep 2026

Modular Lysosome-Targeting Platform Based on a Multivalent DNA Framework for Programmable Protein Degradation.

This work develops a tetrahedral DNA nanostructure-based multivalent lysosome-targeting antibody platform (TDN-MLYTAB) and demonstrates how programmable DNA nanostructures can overcome persistent bioconjugation challenges, advancing modular therapeutics toward application.

Xin Wan, Quan-Hao Dou, Jia-Lin Zeng et al. · 0 citations
Jul 2026

Co-Localization-Gated Multivalent DNA Logic Gate for Programmable Cell Recognition.

This work presents a programmable molecular device that integrates Boolean logic computation with spatial confinement to overcome limitations in affinity, specificity, and off-target binding, and demonstrates a strategy for programming high-fidelity molecular interactions on interested cell surfaces.

Miao Mao, Ying Yang, Yitong Chen et al. · 0 citations

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