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Review Open access Sep 2026

AI-Empowered Viral Metagenomics for Clinical Diagnosis: Advances, Bottlenecks, and Translational Pathways.

Viral metagenomics, leveraging high-throughput sequencing technologies, provides comprehensive, hypothesis-free characterization of viral communities in clinical specimens, establishing itself as a pivotal tool for clinical diagnosis, pathogen discovery, and epidemiological surveillance of viral infectious diseases. Th...

Quan Shen, Wen-Hui Shi, Chao-Ran Liu et al. · 0 citations
Review Open access Aug 2026

Unraveling the Multifaceted Role of TRIM21 in Virus-Triggered Innate Immunity and Diseases

Tripartite motif-containing protein 21 (TRIM21/Ro52) is a pivotal E3 ubiquitin ligase and cytoplasmic fragment crystallizable receptor (FcR). It plays a crucial role in viral infections, autoimmune disorders, and cancers by regulating multiple cell signaling axes, including the NF-κB, RIG-I-like receptor (RLR), cGAS-ST...

Shi-Jin Lan, Ying Wang, Yu-Tong Fu et al. · 0 citations

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