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Quan Yuan

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Open access Jul 2026

Social isolation disrupts prefrontal excitatory-inhibitory balance to impair social novelty memory in adult male mice.

It is established that adult social isolation disrupts social novelty memory processing by shifting the mPFC excitatory-inhibitory balance toward a net hyperexcitable state, revealing a reversible, circuit-specific mechanism for isolation-induced social cognitive deficits.

Quan Yuan, Bing-Yu Ren, Laijian Wang et al. · 1 citation

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