Open access
Jul 2026
Single-cell analysis of the progeria arterial wall reveals progerin-induced progressive, cell type-specific dysfunction and somatic mutation accumulation
It is shown that progerin leads to somatic mutation accumulation particularly in VSMCs, highlighting the need for early, cell-type-specific therapeutic intervention in HGPS to prevent permanent vascular tissue damage.
Lara G. Merino, Gwladys Revêchon, Santhilal Subhash et al.
· Genome Medicine · 1 citation