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Author

Qun Liu

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Open access Sep 2026

Chrysin attenuates diabetes-induced retinal injury by inhibiting microglial GBP3/NLRP3/GSDMD-mediated pyroptosis.

BACKGROUND This study was designed to investigate whether chrysin, a natural flavone, alleviates experimental diabetic retinal disease and to define a microglia-centered mechanism involving guanylate-binding protein 3 (GBP3) and NLR family pyrin domain containing 3 (NLRP3)-gasdermin D (GSDMD) pyroptosis signaling. ME...

Qun Liu, Song-Min Wang, Xuan Chen et al. · 0 citations
Jul 2026

Procyanidin C1 modulates microglia cellular iron homeostasis via targeting HuR/ACSL4 pathway and alleviates high-glucose-induced ferroptosis in diabetic retinopathy.

Investigating the potential role of the RNA-binding protein human antigen R (HuR) in mediating ferroptosis during DR progression, as well as the protective effects of Procyanidin C1 (PC1), demonstrated that PC1 significantly alleviated oxidative stress and ferroptosis in both diabetic mice and high-glucose-treated BV2s...

Qun Liu, Song-Min Wang, Tao Jiao et al. · 0 citations

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