Author

R. A. Floto

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Open access Aug 2026

HANSEN: An Integrated Structural and Functional Proteome Resource for Structure-Guided Drug Discovery in Mycobacterium leprae

Leprosy remains a leading infectious cause of preventable disability, yet its causative agent, Mycobacterium leprae (M. leprae), is structurally under-characterised. Only ten Protein Data Bank (PDB) entries represent seven of its 1,603 protein-coding genes. We present HANSEN, a proteome-wide structural and functional r...

S. Vedithi, Rebecca Rees, Sony Malhotra et al. · bioRxiv · 0 citations

Open access Jul 2026

Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA

An electron cryomicroscopy structure of the 60 kDa CdrA adhesive N-terminus is reported, which combined with electron cryotomography of focused-ion beam milled specimens, allows for a complete in situ model of the native adhesin and reveals a small adhesive domain (called ADEPT) at the distal tip of CdrA that is nearly...

Olivia E. R. Smith, Camila M. Clemente, Antonina Andreeva et al. · bioRxiv · 0 citations