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Author

R. A. Mahmoudian

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Review Open access Oct 2026

Oncogenic RAS as an adaptive signaling ecosystem: context-dependent vulnerabilities and resistance-informed therapeutic design

Direct RAS targeting has progressed from pharmacologic proof of concept to routine treatment for selected KRAS G12C-mutant cancers. KRAS G12C inhibitors and KRAS G12C-EGFR combinations established allele- and lineage-specific treatment paradigms. More recently, the multiselective RAS(ON) inhibitor daraxonrasib became t...

A. Hamidi, O. Moaven, R. A. Mahmoudian et al. · 0 citations
Open access Aug 2026

Context-dependent interactions between immune checkpoint and epithelial-mesenchymal transition programs shape the tumor microenvironment in esophageal squamous cell carcinoma

Findings delineate context-dependent transcriptional interactions between ICP and EMT pathways in ESCC and highlight the complexity of the tumor immune microenvironment beyond single-parameter biomarkers such as TMB.

M. Montazer, Fatemeh Fardi Golyan, Majedeh Ramian Yarasmi et al. · 0 citations

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