Abstract Objective To understand how prevalence estimates of single and multiple organ fibrosis have changed from 2012 to 2022. Design Retrospective population-based cohort study. Setting Data from primary (Clinical Practice Research Datalink Aurum) and secondary care (Hospital Episode Statistics Admitted Patient Care)...
G. M. Massen, Gisli R. Jenkins, R. Allen et al.· BMJ Open· 0 citations
Evidence of shared genetic associations for fibrosis across organs is found, both at individual genetic loci and genome-wide, which highlights specific genes that may contribute to fibrosis across organs and diseases, which may facilitate the development of new therapies.
Ebrima Joof, T. Hernández-Beeftink, G. Parcesepe et al.· BMJ Connections Clinical Gen...· 0 citations
PKN2 loss drives fibroblast reprogramming and aberrant ECM remodelling, establishing PKN2 as an important regulator of pulmonary fibroblast homeostasis and tissue repair.
Catherine E. McMullan, Oscar A. Peña, P. Rajasekar et al.· bioRxiv· 0 citations
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