Ancestry-Based Disparities in Cardiovascular Outcomes and Polygenic Risk Among Adults with Congenital Heart Disease in the All of Us Research Program.
Most individuals born with congenital heart disease now survive to adulthood, producing a growing population at risk for major adverse cardiovascular events (MACE). Ancestry-based disparities are incompletely characterized and polygenic risk has not been related to outcomes. We analyzed 6,771 adult ACHD participants in...