INTRODUCTION
Cell-free DNA (cfDNA) is a promising non-invasive biomarker of organ injury. In transplantation, cfDNA is typically quantified by distinguishing donor- from recipient-derived DNA. However, we aimed to develop a multiplex digital droplet PCR (ddPCR) assay to measure kidney-derived cfDNA independent of donor...
Ann-Maria Gramkow, M. Jørgensen, H. Thiesson et al.· Clinical Biochemistry· 0 citations
Lung cancer remains the leading cause of cancer-related death worldwide, largely due to late-stage diagnosis. Although low-dose computed tomography (LDCT) screening can reduce mortality, it is limited by high false-positive rates, radiation exposure, and low adherence. Thus, there is an urgent need for precise, accessi...
Peter Hjorth-Hansen, C. Jacobsen, L. Nederby et al.· Journal of Molecular Diagnos...· 0 citations
Background: Lung cancer is a heterogeneous disease with unpredictable trajectories. Risk stratification in lung cancer remains imprecise within tumor-node-metastasis (TNM) stages. Objectives: This work aims to evaluate whether methylated circulating tumor DNA (ctDNA) can improve prognostication at the time of diagnosis...
Peter Hjorth-Hansen, L. Nederby, C. Jacobsen et al.· Therapeutic Advances in Medi...· 0 citations
Findings show that the MRMC framework was feasible in a practice-proximate setting and the trends merit further evaluation in larger cohorts and earlier diagnostic settings.
Peter Hjorth-Hansen, S. Wen, T. Hansen et al.· Scientific Reports· 0 citations
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