OBJECTIVE
Cognitive impairment is associated with language changes that emerge during verbal responses to neuropsychological assessments that traditional scoring does not capture. The current study investigated the utility of a linguistic analysis of paragraph recall responses for detecting cognitive impairment.
METH...
Se-Hee Park, Nicole Roth, Megan Barker et al.· Journal of the International...· 0 citations
Previously derived polygenic risk scores (PRSs) for Alzheimer’s disease (AD) perform inconsistently across diverse ancestries. We developed an APOE-independent multiancestry AD PRS using genome-wide association study summary statistics applied to European ancestry, African American, Caribbean Hispanic and East Asian co...
N. Kurniansyah, S. Tasaki, H. Rehman et al.· Nature Genetics· 0 citations
Background Whether plasma protein associations with Alzheimer’s disease (AD) differ by genetic risk remains unclear. Methods We studied 18,212 UK Biobank participants aged ≥ 60 years with Olink Explore 3072 proteomic data, APOE genotypes, and AD polygenic risk scores. Protein-by-genetic risk interactions were screened,...
Yuan-Ming Leng, Hui-Tong Ding, Jian Yang et al.· Research Square· 0 citations
BACKGROUND
Daily heart rate (HR) and physical activity are biomarkers of cardiovascular disease. A smartwatch-derived metric, daily HR per step (DHRPS), has also been associated with cardiovascular disease. Integrating smartwatch data with neuropsychological assessments in older adults makes it possible to capture subc...
Jie He, Yuan-Kai Zhang, Xuzhi Wang et al.· Journal of the American Hear...· 0 citations
Associations between a sleep-derived brain health score in mid-to-late life and subsequent cognitive decline in memory, executive function, and language are demonstrated, providing additional support for the potential utility of using this data-driven sleep score as a digital biomarker for the risk of cognitive decline...
Francesca R. Marino, W. Ganglberger, Hao-Qi Sun et al.· SLEEP Advances· 0 citations
