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Oct 2026

Design and synthesis of new 2-aminopyrimidine-thiazolidinone hybrids with enhanced antimicrobial activity: in-vitro evaluation and multiscale computational studies.

A series of novel 2-aminopyrimidine-thiazolidinone hybrids were designed, synthesized, and evaluated for antimicrobial activity against selected bacterial and fungal pathogens. Structural characterization was accomplished using FT-IR, NMR, and mass spectrometry. Among the synthesized compounds, SPRB21 exhibited the mos...

Sabnam Parveen, Sheikh Murtuja, M. Rakhade et al. · 0 citations
Review Open access Sep 2026

Structure and Target‐Based Insights into the Antimicrobial Potential of 1,4‐Dihydropyridine Derivatives

Antimicrobial resistance (AMR) represents a critical global health crisis, eroding the efficacy of conventional therapies and necessitating the urgent discovery of novel agents with an innovative mechanism of action. A privileged structure in medicinal chemistry, the 1,4‐dihydropyridine (1,4‐DHP) scaffold has shown g...

Arshleen Kaur, R. Babbar · 0 citations

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