Author

R. Backofen

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Open access Sep 2026

Unveiling the small protein landscape of uropathogenic E. coli

Uropathogenic Escherichia coli (UPEC) is the predominant causative agent of urinary tract infections. The UPEC strain, CFT073, has a mosaic genome containing 60 genomic islands enriched in virulence genes. In this study, we explore the small proteome of CFT073 using ribosome profiling (Ribo-seq) coupled with RNA sequen...

Wen-Ting Liu, R. Gelhausen, Lisa Werland et al. · bioRxiv · 0 citations

Open access Jul 2026

Systematic Benchmarking of CRISPR-Cas9 Off-Target Prediction Tools Reveals Limitations and Implications for Preclinical Assessment.

Accurate identification of CRISPR-Cas9 off-target sites is essential for the safety assessment of genome-editing-based therapies. While numerous in silico prediction tools have been developed, their comparative performance and practical utility in preclinical workflows remain incompletely defined. We performed a system...

M. M. Kaufmann, Maren Hackenberg, William Jobson Pargeter et al. · Human Gene Therapy · 0 citations