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Open access Aug 2026

Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice

Abstract Severe disease following infection with SARS-CoV or SARS-CoV-2 is driven in part by genetically regulated immune responses that promote lung injury. To study genetic mechanisms of immune-mediated coronavirus pathogenesis, we screened the Collaborative Cross (CC) panel for Mus musculus strains that are phenotyp...

Ellen L. Risemberg, S. Leist, A. Schäfer et al. · 0 citations
Open access Sep 2026

Aminopeptidase N is a receptor for hedgehog merbecoviruses.

Three coronavirus receptors from European hedgehogs are tested in cell-based assays and aminopeptidase N (APN) is identified as a receptor for hedgehog merbecoviruses, broadening understanding of receptor use across merbecoviruses and betacoronaviruses and inform risk assessments for viral emergence.

M. Jin, Victoria A. Jefferson, Zhe Zhao et al. · 1 citation

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