FL-Net is a novel federated clinical research framework that integrates modular data harmonization, data discovery, disclosure control, securely built versioned FL-Net-Tools and containerized federated workflow execution into a persistent network and enables the re-use of harmonized data and workflows across studies.
Simon Süwer, Juliane Klemm, E. Acitelli et al.· arXiv.org· 0 citations
Background and Objectives Fc gamma receptor 3A (FCGR3A) V158F polymorphism has been shown to modify the response to anti-CD20 therapy across several autoimmune diseases. Ocrelizumab (OCR), an anti-CD20 agent, suppresses inflammatory activity in multiple sclerosis (MS), yet whether FCGR3A V158F polymorphism affects its...
G. Abbadessa, U. Chianese, Claudia Russo et al.· Neurology(R) neuroimmunology...· 0 citations
Federated learning enables collaborative training without sharing patient-level data, but most studies remain simulations. Based on five requirements derived from the literature, we analyzed 14 FL frameworks and found that none fully satisfied these requirements. We present FL-Net, a novel federated clinical research f...
Simon Süwer, Juliane Klemm, E. Acitelli et al.· 0 citations
Current knowledge on the interplay between DNA and RNA methylation in regulating tumor plasticity is summarized, highlighting emerging mechanistic insights, functional interactions, and potential implications for future epigenetic and epitranscriptomic therapeutic strategies.
Guglielmo Bove, U. Chianese, Antonio Beato et al.· Seminars in Cancer Biology· 0 citations
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