Author

R. Bonami

3 papers indexed here

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Open access Oct 2026

Transcriptionally distinct atypical B cell populations contribute to insulin autoreactivity and show differential activation, isotype switching, and somatic hypermutation in early-stage type 1 diabetes individuals

Autoreactive B cells must escape immune tolerance mechanisms to drive autoimmune disease, potentially through alternative paths to memory and antibody-secreting cell formation. “Atypical” B cells represent one such alternative pathway and are expanded in several human autoimmune diseases. Atypical B cells display pheno...

Lindsay E. Bass, Landon M. Clark, Bryan Han et al. · bioRxiv · 0 citations

Open access Aug 2026

SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes

The essential role of SAP in mediating proinflammatory, anti-insulin B-T interactions to support T1D is highlighted, which led to reduced pro-inflammatory CD8+ T cell formation and islet-reactive progenitor exhausted CD8+ T cells in pancreata.

Landon M. Clark, Dudley H. McNitt, Jack C. McAninch et al. · bioRxiv · 0 citations

Open access Jul 2026

B cells in Takayasu’s arteritis upregulate genes involved in RNA splicing, protein synthesis, and BCR signaling compared to healthy individuals 2258135

TAK patient B cells exhibit a distinct transcriptional program that might support interactions with autoreactive T cells and contribute to autoimmune disease liability and future studies will be required to evaluate the functional consequences of these changes with respect to tissue damage in vasculitis.

Gabriel J. Rodriguez-Garcia, R. Corty, Amber Gooch et al. · Journal of Immunology · 0 citations