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Robert P. Bonin

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Open access Sep 2026

Characterization of the Grin1Q536R/+ mouse: a preclinical model for GRIN1-related neurodevelopmental disorder

N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors playing critical roles in brain development, synaptic plasticity, and cognition. GRIN1-Related Neurodevelopmental Disorder (GRIN1-NDD) is a rare genetic condition caused by pathogenic variations in the GRIN1 gene, which encodes the obligatory su...

Megan T. Sullivan, Yuan-Ye Yan, Lyra Vania et al. · 0 citations
Open access Aug 2026

Therapeutic potential of a novel PPARγ agonist in a mouse model of HIV-associated neurocognitive impairment.

HIV-associated neurocognitive impairment (NCI) affects up to 50% of individuals living with HIV, causing cognitive, motor, and behavioral deficits, largely driven by brain inflammation. Activation of peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor primarily involved in regulating lipid...

Celene Titus, Md Tozammel Hoque, R. Bonin et al. · 0 citations

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