R. C. Allpas

Fast Diffusion-Based Metabolomics Profiling by 3D Pure Shift HSQC-DOSY NMR with COLMARvista

Peak overlap is a major obstacle for comprehensive metabolite profiling in NMR-based metabolomics. It is most severe for 1D 1H NMR spectra but can also persist for 2D NMR. Here, we demonstrate how metabolite-specific translational diffusion coefficients obtained from a pure shift pseudo-3D HSQC-DOSY experiment can reso...