Author

R. D. de Freitas

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Open access Nov 2026

Anterior insular cortex neurostimulation modulates sensory hypersensitivity and pain-related emotional behaviors in a rat model of chronic neuropathic pain.

BACKGROUND AND AIMS Chronic neuropathic pain (NP) is frequently accompanied by anxiety- and depression-like behaviors that contribute to functional impairment. The insular cortex plays a central role in pain processing and interoceptive regulation, with the anterior insular cortex (AIC) critically involved in integrati...

R. M. Acunha, Priscila Medeiros, H. Machado et al. · Physiology and Behavior · 0 citations

Open access Sep 2026

469. The serotonin 5-HT2A agonist psilocybin in the treatment of neuropathic pain

Abstract Background Pain conditions are major health problems resulting in physical, psychological and social impairment (1), and health care costs (2,3). Within the last decade, research has demonstrated that 5-HT2A agonists including psilocybin and LSD elicit spiritual experiences (4) and functional connectivity chan...

E. Nield, M. López-Canúl, A. Inserra et al. · International Journal of Neu... · 0 citations

Sep 2026

Infralimbic cortex neurostimulation attenuates nociceptive and affective manifestations in a reserpine-induced fibromyalgia model.

It is suggested that the IL exerts an inhibitory role in the modulation of pain and psychiatric comorbidities in FM, suggesting potential circuits between the IL and the salience network in modulating the manifestations of FM.

Railson Carlos Olinto de Brito, Fernando René Bendaña-Córdoba, N. C. Coimbra et al. · Physiology and Behavior · 0 citations