coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture
M. Langereis, Q. Zeng, B. Heesters et al.
· 0 citations
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Open access
Aug 2026
Spike and host glycan determinants of HKU1 airway tropism
It is shown that spikes from both serotypes of HKU1 preferentially bind 9-O-acetylated α2,8-linked disialosides, and molecular dynamics simulations indicated that membrane-embedded GT3, but not GD3, presents its glycan chain in a geometry compatible with S1A-mediated engagement.
Robert Creutznacher, Louisa Elizabeth Wallace, Oliver J. Debski-Antoniak et al.
· bioRxiv · 0 citations