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Author

R. de Francesco

2 papers indexed here

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Open access Sep 2026

Gapmers targeting conserved SARS-CoV-2 single-stranded regions reduce viral load and reshape inflammatory macrophage responses

Summary The COVID-19 crisis is now over, but additional viral strains of SARS-CoV-2 that evade immunity are continuously emerging. We explored the design, evaluation, and optimization of anti-sense oligonucleotides (ASOs) targeting SARS-CoV-2 RNA, with the aim of providing a scalable strategy capable of responding to e...

Greta Gallo, L. Donnici, L. S. Colley et al. · 0 citations
Open access Aug 2026

Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection

Intracellular pathogens are ideal candidates for modelling the pathophysiology of chronic infection, as they hide within host cells and avoid immune clearance by reshaping cellular fate. This study unveils how the intracellular pathogen Mycobacterium abscessus (Mab) reprograms alveolar macrophages towards a senescent s...

E. Scarpa, D. Oliveri, D. Rondelli et al. · 0 citations

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