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Review Open access Sep 2026

268. Targeting glutamatergic dysregulation in severe treatment-resistant obsessive-compulsive disorder: integrating serotonergic, dopaminergic, and glutamatergic therapies

Abstract Background Obsessive-Compulsive Disorder (OCD) is a chronic and disabling psychiatric condition affecting 2–3% of the population. While selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT) remain first-line treatments, up to 40% of patients exhibit treatment-resistant OCD (TR-...

B. Fernández, R. Diós, J. Justo · 0 citations

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