Author

R. E. Frye

2 papers indexed here

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Review Open access Sep 2026

Epigenetic Hierarchies in Autism from Folate–SAM Metabolism to LSD1 and G9a

Autism spectrum disorder (ASD) is a diverse neurodevelopmental condition involving interactions among genetic, environmental, metabolic, immune, synaptic, and epigenetic factors. This review explores whether disruptions in folate-dependent one-carbon metabolism and S-adenosylmethionine (SAM) availability may increase e...

N. Pérez, Aina Bellver, Fahad Hussain et al. · Biomolecules · 0 citations

Open access Sep 2026

Cunermuspir, a Copper(I)–Niacin Complex, Modulates Mitochondrial Respiration and Cellular Oxidant Handling in Fibroblasts from Children with Autism Spectrum Disorder

Copper is a redox-active transition metal that is essential for the assembly and catalytic function of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain and a principal site of physiological oxygen reduction. Elevated Complex IV activity and respiratory chain uncouplin...

Sophie Wallace, Spencer Lawes, Adrienne C. Scheck et al. · Antioxidants · 0 citations