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Open access Aug 2026

Group sequential designs and a sample size reestimation approach for partially nested trials

Randomized controlled trials are the gold standard for evaluating interventions. For individually randomized trials, clustering can exist in the intervention arm but not the control arm when the intervention is delivered by study personnels and/or in a group setting. This results in a partially nested design, whi...

Kim May Lee, Aritra Mukherjee, R. Emsley · 0 citations
Review Open access Aug 2026

The extent of Patient and Public Involvement and Engagement in Sequential Multiple Assignment Randomised Trials: A scoping Review.

BACKGROUND Sequential Multiple Assignment Randomised Trials (SMARTs) offers a robust methodology for developing adaptive, personalised interventions, but their unfamiliarity may limit accessibility for patients and the public. Patient and public involvement and engagement (PPIE) makes research more relevant, acceptable...

Isaac J. Egesa, Faye D. Baldwin, M. Wells et al. · 0 citations

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